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Depakote ER was significantly more effective than placebo in reduction of the Mania Rating Scale (MRS) total score.

In a clinical trial, the Depakote ER dose was initiated at 25 mg/kg/day and increased by 500 mg/day PO on Day 3. The dose was then adjusted to clinical response with a trough plasma concentration between 85 to 125 mcg/mL. Depakote ER was significantly more effective than placebo in reduction of the Mania Rating Scale (MRS) total score.

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Valproic acid is an epilepsy medication that is now used for the treatment of panic attacks as well as other  21 May 2013 FDA is advising that anti-seizure medication valproate is use of valproate- containing drugs, including Depakote and Depakene, during pregnancy: to the drug labels, and valproate's pregnancy category for migrain 14 Jun 2013 Depakote (valproic acid) is an antiepileptic drug that is also known as Pre- 2013: No warning of Pregnancy Category X for migraine and no  7 May 2015 The Food and Drug Administration classified Depakote into pregnancy category D due to its likelihood of causing serious and potentially  Top 300 Pharmacy Drug Cards.